Ghostbusters: Afterlife has a Harold Ramis dedication in the credits since the story itself became an intergenerational Spengler story
Ghostbusters: Afterlife has a dedication to Harold Ramis, who played Egon Spengler in the original Ghostbusters films. Ramis was joined by Bill Murray, Dan Aykroyd, and Ernie Hudson in the 1984 original directed by Ivan Reitman and returned to the role for the sequel, Ghostbusters II, in 1989. Ramis passed away in 2014 from autoimmune inflammatory vasculitis, leaving behind a tremendous legacy of work, including his acting and writing work on the phenomenon that is the Ghostbusters franchise.
The first two films in the franchise were directed by Ivan Reitman, who also worked with Ramis early on with films like National Lampoon’s Animal House, Stripes and Meatballs. Reitman would go on to direct a string of notable films, including Twins, Kindergarten Cop, Dave, and Draft Day, while Ramis would appear in several films, as well as writing and directing a number of comedy classics, including Groundhog Day, Multiplicity, Bedazzled, and Analyze This and Analyze That. Numerous attempts were made to make a third Ghostbusters film, but that ultimately never came to fruition, eventually leading to a hard Ghostbusters reboot in 2016 without the original characters.